$169,532
IHUT (Intracranial and Intraventricular Hemorrhage with Ultrasound Enhanced Thrombolysis)
Swedish Neuroscience Institute
Co Applicants: EKOS Corporation, Johns Hopkins University School of Medicine
Co Investigators: Daniel Hanley MD, Robert L. Wilcox
Dr. Newell is co-executive director of the Swedish Neuroscience Institute. Board-certified in neurological surgery, he specializes in the microsurgical treatment of the spine and cerebrovascular systems. He is one of the northwest region's premier experts in cerebral aneurysm and an author of the leading medical textbook on the subject: "Management of Cerebral Aneurysms." He also has specialized expertise in arteriovenous malformations, stroke, extracranial to intracranial bypass, minimally invasive spine surgery, skull base surgery and surgery for brain tumors.
Intracranial hemorrhage (ICH) is a type of stroke which occurs most commonly due to the effects of hypertension (high blood pressure) causing rupture of a fragile blood vessel and bleeding directly into the brain. This condition occurs in 11 to 31 of 100,000 Caucasians, and at about 1.4 times that rate in African Americans and Asians. For Washington's 5.8M citizens, that is up to 2,000 patients per year. Thirty day mortality in ICH is estimated at 40 to 60%, with most deaths occurring in-hospital.
This Pilot Human Safety Study will evaluate a combination of recombinant tissue plasminogen activator (rt-PA) and catheter delivered ultrasound in patients with ICH for clot lysis and drainage of the hemorrhage. Catheter delivered, ultrasound enhanced thrombolysis has been shown in more than 1,000 patients to be safe and effective when introduced inside the blood vessels in the peripheral and neuro-vasculature.
This proposal is for a Pilot Human Use Safety Study of a new therapy for ICH. We will combine a novel technology of image-guided surgical catheter placement (GPS guidance within the brain) with delivery of rt-PA and ultrasound enhancement, for clot lysis and drainage. This is an opportunity to change the practice of medicine, with ultrasound and drug delivery catheters that were developed, and are manufactured, in Washington State. The success of this effort will affect a large population of the state's most ill patients. Success in the market will increase the company's production and support staff in Washington.
From our "In the News" section:
| Mar 5, 2010 | Ekos, Swedish Aim to Shake Up Stroke Treatment with Ultrasound Brain Clot Buster [ XCONOMY ] |
| Feb 25, 2010 | ASA: Ultrasound Speeds Drainage of Brain Hemorrhages [ MEDPAGE TODAY ] |
| Dec. 23, 2009 | 'I was holding Ray's brain in my hand' [ SEATTLE POST INTELLIGENCER ] |
Modified: 03/05/10